Trabectedin cardiotoxicity
Splet10. avg. 2024 · Trastuzumab-induced cardiac dysfunctions were regarded as less severe and largely reversible because primary cardiomyocyte did not show ultrastructure changes that were associated with anthracycline-induced cardiotoxicity, and primary myocyte injury did not occur in patients that were treated with trastuzumab [ 18 ]. SpletCardiotoxicity is defined as the advent of cardiac muscle dysfunction, such as left ventricular ejection fraction (LVEF) due to exposure to antineoplastic therapy, which may …
Trabectedin cardiotoxicity
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Splet10. avg. 2024 · However, cardiotoxicity associated with its clinical application poses challenges for clinicians and patients, mechanisms of which are still evolving. This … SpletTrabectedin is a chemotherapeutic used to treat advanced soft tissue sarcoma and relapsed platinum-sensitive ovarian cancer. Although it is associated with a low …
SpletTrabectedin is a chemotherapeutic used to treat advanced soft tissue sarcoma and relapsed platinum-sensitive ovarian cancer. Although it is associated with... DOAJ is a … Splet08. mar. 2024 · Chimeric antigen receptor-T cell-related neurotoxicity has been termed immune effector cell-associated neurotoxicity syndrome (ICANS). 18 Signs and symptoms can be broad, including confusion, dysgraphia, language disturbance, seizures, agitation, and somnolence.
SpletTrabectedin is a chemotherapeutic used to treat advanced soft tissue sarcoma and relapsed platinum-sensitive ovarian cancer. Although it is associated with a low … Splet12. apr. 2024 · Tyrosine kinase inhibitors (TKIs) can cause serious cardiotoxicity [ 1, 2 ]. Left ventricular ejection fraction (LVEF) has been found to progressively fall in groups of …
Splet15. jun. 2024 · Soft tissue sarcoma (STS) is a biologically heterogeneous malignancy with over 50 subtypes. Historically, there have been few systemic treatment options for this relatively rare disease. Traditional cytotoxic agents, such as anthracyclines, alkylating agents, and taxanes have limited clinical benefit beyond the first-line setting; across all …
Splet06. nov. 2013 · Trabectedin is a tetrahydroisoquinoline molecule that binds to the N2 of guanine in the minor groove, causing DNA damage and affecting transcription regulation … 42条1項2号道路 私道 制限Splet30. jan. 2024 · Trabectedin is an anti-neoplastic drug that originates from the marine Caribbean tunicate Ecteinascidia turbinata. The authors retrospectively identified … 42条1項2号道路 通行Splet18. mar. 2011 · Purpose This analysis provides a cross-study evaluation of the cardiac safety of trabectedin. Methods Drug-related cardiac adverse events (CAEs) were … 42条1項1号SpletTrabectedin has been argued to exert radiosensitization action through interference with the DNA repair mechanisms 11 or by inducing arrest in the G2/M phase of the cell cycle, … 42条1項4号道路の指定SpletFluoroquinolones and bedaquiline can cause prolongation of the QT interval. QT interval prolongation is associated with an increased risk of developing ventricular arrhythmias. … 42条1項4号 申請SpletTrabectedin Cardiotoxicity in Soft Tissue Sarcoma: A Case Series and Clinical Insights David G. Gent * , Nasim Ali, Anna Olsson-Brown, Gregory Y. H. Lip , David J. Wright, … 42条1項4号 指定番号SpletTrabectedin is a chemotherapeutic used to treat advanced soft tissue sarcoma and relapsed platinum-sensitive ovarian cancer. Although it is associated with a low incidence of cardiotoxicity, when this occurs it can be fatal or significantly. 42条1項3号道路 幅員