Hth-01-015
Web1 jan. 2014 · WZ4003 and HTH-01-015 suppress NUAK1-mediated MYPT1 phosphorylation. To evaluate whether WZ4003 and HTH-01-015 could suppress NUAK activity in vivo, we … Web30 jul. 2024 · N-myristoyltransferase (NMT) inhibitors that were initially developed for treatment of parasitic protozoan infections, including sleeping sickness, malaria, and leismaniasis, have also shown great promise as treatment for oncological diseases. The successful transition of NMT inhibitors, which are currently at preclinical to early clinical …
Hth-01-015
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WebHTH-01-015 inhibited the phosphorylation of the NUAK1 substrate, MYPT1. The phosphorylated site was identified as Ser445. In HEK cells overexpressing drug-resistant … WebHTH-01-015 inhibited the phosphorylation of the NUAK1 substrate, MYPT1. The phosphorylated site was identified as Ser445. In HEK cells overexpressing drug-resistant …
WebThe results of the present study indicate that WZ4003 and HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases. Expand. 59. PDF. … WebHTH-01-015 Synonym (s): 5,13-Dihydro-4,5,13-trimethyl-2- [ [1- (4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho [2,3-e]pyrimido [5,4-b] [1,4]diazepin-6-one Empirical Formula (Hill Notation): C26H28N8O CAS No.: 1613724-42-7 Molecular Weight: 468.55 Match Criteria: Keyword All Photos ( 1) DMA-135
WebThe inhibitors WZ4003 and HTH-01-015 belong to the first generation of NUAK inhibitors and can be considered relatively specific, as they inhibited the NUAKs without inhibiting … WebBarrier integrity B cell (activation) Cellular signalling Chemotaxis & migration Cytokine production & signalling Immune regulation Immune system development Inflammation T cell (activation) Tissue repair Cell Types B-cells Dendritic cells Granulocytes Innate lymphoid cells Macrophages/monocytes Mast cells Natural killer (NK) cells
WebHTH-01-015 是一种有效的选择性 NUAK1 抑制剂，比作用于NUAK2的选择性高100多倍。 Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations.
WebTGF-β is a growth factor implicated in a plethora of processes and malignancies, which include cancer and fibrosis. Via binding to its receptor, TGF-β activates a complex intracellular signal transduction pathway, which is controlled by many forms of positive as well as negative feedback. towne point club norfolk vaWeb8 apr. 2024 · However, even with long term administration of antiviral HTH-01-015 providers, the incidence of HZ raises after discontinuation of prophylaxis [4, 13]. Although necessary, there is not plenty of evidence to support a minimum interval between transplantation and … towne point rd portsmouth vaWebHTH 01-015 is a potent and selective NUAK1 inhibitor (IC 50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. … towne point park eventstowne point landing apartmentsWeb2 mei 2024 · AMPK-related protein kinase 5 (ARK5) is a serine/threonine kinase that has been identified as the fifth member of the AMP-activated protein kinase (AMPK) family ( 4 ). ARK5 serves a role in the metastasis and invasion of colorectal (CRC) cancer, pancreatic cancer (PC), gastric cancer, hepatic cancer and squamous cell carcinoma ( 5-8 ). towne point landing apartments portsmouth vaWeb21 mrt. 2024 · Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. towne point suitesWebHTH-01-015 Solid 2887-5: 5 mg 2887-25: 25 mg See below SECTION 3: HAZARDS IDENTIFICATION Components CAS Number EC-No. Molecular Weight Chemical Formula HTH-01-015 1613724 -42 7 -- 468.55 C 26 H 28 N 8 O HTH-01-015: Emergency Overview: OSHA Hazards: No known OSHA hazards GHS Classification: Not a dangerous … towne point elementary school