Glutamine synthetase in diabetic retina
WebDec 16, 2015 · This study investigated the effects of resveratrol (RSV) on retinal functions, glutamate transporters (GLAST) and glutamine synthetase (GS) expression in diabetic … WebGlutamine synthetase (GS) is an ATP-dependent enzyme found in most species that synthesizes glutamine from glutamate and ammonia. In brain, GS is exclusively located …
Glutamine synthetase in diabetic retina
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WebFeb 6, 2024 · Besides the uptake of glutamine by M2 macrophages, their accumulation of glutamine may also involve their synthesis of glutamine from glutamate and ammonia via glutamine synthetase (GS). GS is barely detectable in M1 macrophages but is highly expressed in M2 macrophages, particularly in response to IL-10 ( 61 ). WebRetinal degeneration is a leading cause of incurable vision loss and blindness. The increasing incidence of retinal degeneration has triggered research into the development of in vitro retinal models for drug development and retinal alternatives for transplantation. ... The glial marker glutamine synthetase was observed in both bioinks; however ...
WebMar 21, 2011 · The aim of the present study was to examine the expression of glutamine synthetase (GS) in rat retinal Müller cells induced by different levels of hydrostatic pressure using a novel pressure mechanism. pH, PCO2 or PO2 in culture medium as determined by gas analysis was used to examine the pressure mechanism. GS expression in the Müller … WebJun 1, 2000 · The activity and content of glutamine synthetase were also significantly reduced in retinas from rats diabetic for 2–6 months [range of 48% ( P < 0.005) to 83% ( P < 0.05) compared to control]. The activity of glutamine synthetase was normalized by acute injections of insulin, but not by reducing blood sugar levels with injections of phlorizin.
WebSep 4, 2024 · 4. Discussion. The purpose of the current study was to determine the effect of ethanol garlic (A. sativum) extract on activities of hippocampus Na + /K + ATPase, glutamine synthetase, and Ca 2+ ATPase in streptozotocin-nicotinamide induced in diabetic Wistar rats as possible mechanisms for memory improvement.Results showed … WebNov 22, 2024 · Although DR is clinically described as diabetes-induced damage to the retinal blood vessels, several studies have reported that metabolic dysregulation occurs in the retina prior to the. Diabetic retinopathy (DR) is the leading cause of vision impairment in working age adults. ... (GAPDH) and glutamine synthetase (GS) in an in-vitro model of …
WebMar 1, 2024 · Diabetic Retinopathy; Glaucoma; Inherited Retinal Degeneration Clinic ... Loss of glutamine synthetase immunoreactivity from the retina in canine primary glaucoma. Vet Ophthalmol. 2008 May-Jun;11(3):150-7. doi: 10.1111/j.1463-5224.2008.00581.x. ... Although the redistribution resembles that induced by ischemia, …
WebJul 19, 2011 · Purpose: A predominant function of Müller cells is to regulate glutamate levels, but in diabetic retinopathy (DR) the function is compromised.The present study was performed to investigate the role of pigment epithelial-derived factor (PEDF) on the expression of glutamine synthetase (GS) in retina of diabetic rats. two features of monopolistic competitionWebFeb 2, 2011 · Because of impaired glutamine synthetase (Lieth et al. 2000b) or impaired Müller cell glutamate uptake and disposal ... The differences between control and … talkin cowboys phone numberWebMay 31, 2011 · Glutamine synthetase (GS), a Müller cell specific enzyme in the retina, is the key enzyme involve in glutamate metabolism. The goal of this study was to investigate the expression and regulation of GS by insulin in the cultured rat retinal Müller cells. Immunocytochemical and immunoblotting experiments showed that the cultured Müller … talkin cowboys twitterWebMay 1, 2016 · The effect of pigment epithelium-derived factor on expression of glutamine synthetase in diabetic rat retina. Chin J Ocul Fundus Dis. 2010; 2:155–59. [Google … talkin cowboys hostsWebMar 30, 2010 · Background The pathogenesis of diabetic retinopathy (DR) is similar to that of a chronic inflammatory disease. A predominant function of Müller cells is to regulate glutamate levels, but in DR the function is compromised. The present study was performed to investigate the role of pigment epithelial derived factor (PEDF) on the expression of … two features of hormonesWebAug 29, 2024 · Glutamine synthase (Gene name: GLUL), a retinal Müller cell marker, was found as an oxidation target protein in a glaucoma rat model and was shown to be up-regulated in retinal rat Müller cells by hypertension . In addition, GLUL seems to play a key role in the retinal glutamate/glutamine cycle in hypertensive eyes . two features of peninsular plateauWebNov 3, 2024 · In a diabetic rat retina model, RSV could protect retinal function in high glucose-induced retinal dysfunction via elevating glutamate uptake, enhancing glutamine synthetase activity, and increasing glutamine synthetase and glutamate transporters expression . RSV also regulated glutathione (a tripeptide composed of three amino acids … two features of smart materials