Fractionation sensitivity
WebMar 15, 1999 · Fractionation sensitivity and cellular proliferation. While it is generally accepted (28) that most tumors show a lower sensitivity to fractionation (typical α/β values of 10–12 Gy) than most late-responding normal tissues (typical α/β values of 2–4 Gy), it has long been known that there are exceptions to this general trend. WebApr 8, 2024 · Collateral sensitivity (CS), whereby resistance to one drug is accompanied by increased sensitivity to another, provides new opportunities for antimicrobial drug discovery. Here, Liu et al. screen ...
Fractionation sensitivity
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WebJan 20, 2024 · A meta-analysis of randomized trials looking at dose-response and fractionation sensitivity of prostate EBRT indicated a shallow, but highly significant, dose-response relationship. 29 Although Vogelius et al. suggested saturation might be present in the dose-effect at an EQD2 of > 80 Gy, the FLAME trial (EQD2Gy 115.8 Gy with an a/b … Web12 hours ago · Within rice plant, the degree of isotope fractionation in different tissues was significantly different, but the fractionation trend under different treatments was consistent. Generally, roots were preferentially enriched in light Cd than the aboveground part, with the δ 114/110 Cd value of −0.57‰ (DY), −0.47‰ (AWD), and −0.43‰ (FL ...
Webper fraction and the fractionation sensitivity of the tissue. Two asymptotic properties are also clear: lim d r 0 g N 2 g d (5) and lim d r 00 g N g d (6) Equation 6 is intuitively clear: tissues with a/b / / d r will exhibit low fractionation sensitivity, and it is the fractionation effect that causes the double trouble phenomenon. WebNov 1, 1994 · The fractionation sensitivity (α/β) of ten human melanoma xenograft lines was measured in vivo and related to cellular radiation sensitivity measured in vitro. Xenografted tumours were irradiated under clamped conditions with 2, 4, 8 or 16 fractions within a constant overall treatment time of 5 days. At least three different fractional doses ...
Webthe fractionation sensitivity of tissues. Key words: Therapeutic radiology; fractionation methods, NSD concept, historical review. The purpose of this paper is to outline the evolution of fractionation practices in the early years of radiotherapy, from which interest in the time factor arose, and to show how this led ultimately to the NSD concept. WebMay 21, 2024 · The fractionation sensitivity of hematologic malignancies is underreported in clinical series. ... Other fractionation schemes could …
WebAug 11, 2024 · Yarnold J, Ashton A, Bliss J, et al: Fractionation sensitivity and dose response of late adverse effects in the breast after radiotherapy for early breast cancer: Long-term results of a randomised trial. …
WebMar 19, 2024 · The two test dose regimens in START-P were 13-fraction regimens estimated to be isoeffective with 50 Gy in 25 fractions based on α/β-values of 6 and 3 Gy respectively, representing the highest and lowest estimates of fractionation sensitivity of the dose-limiting late-reacting normal tissues of the breast/ribcage consistent with the ... forklift tyre manufacturers in indiaWebApr 1, 2005 · The α/β value of 3.6 Gy (95% CI 1.8–5.4) for change in breast appearance is consistent with indirect estimates of fractionation sensitivity in a range of human non … difference between lay and lyingWebJun 19, 2008 · The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid … forklift types classWebAug 28, 2024 · A low α/β value for a particular end-point indicates the high fractionation sensitivity of the underlying target cells and the close relationship between the total dose needed to produce the ... difference between layed and laidWebMar 15, 2024 · Breast and prostate cancers may generally have a lower alpha-beta ratio than the head and neck squamous cell carcinomas that were evaluated to derive an initial understanding of sensitivity to dose fractionation. 5 However, questions remain about whether the lower alpha-beta ratio is specific to hormone-sensitive subtypes, which … forklift \u0026 mining spares cchttp://irochouston.mdanderson.org/RPC/CREDENTIALING/files/0415.pdf forklift unit of competencyWebJul 10, 2015 · The fractionation sensitivity of any tissue is characterized by its α/β value; the α/β value is a mathematically calculated term derived from the dose-effect curve of the tissue, given in units of Gray (Gy). Generally, the α/β values of healthy tissues for late reactions are low (in the range of 2-3 Gy). ... forklift tyres wetherill park